PT-141 (Bremelanotide) (10mg) Dosage Protocol
PT-141 (Bremelanotide) is a melanocortin receptor agonist FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women. It works through the central nervous system.
Add 2.0 mL bacteriostatic water → 5 mg/mL
1.75mg as needed, max once per 24 hours
At 5 mg/mL: 35 units = 1.75mg (FDA-approved dose)
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 4 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| As Needed | 1.75mg | 35 units (0.35 mL) |
| Timing | 45+ min before activity | Single dose |
| Maximum | Once per 24 hours | 8 doses/month max |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
PT-141 activates melanocortin receptors (MC3R/MC4R) in the central nervous system rather than acting on the vascular system. Clinical trials established 1.25mg and 1.75mg as effective doses, with 0.75mg being ineffective. Effects typically begin 45 minutes after injection.
- FDA-approved for HSDD in premenopausal women
- Works through central nervous system
- Does not affect blood pressure like PDE5 inhibitors
- On-demand dosing as needed
- Clayton AH, et al. Bremelanotide for Female Sexual Dysfunctions. J Sex Med. 2016;13(3):411-22
- Edinoff AN, et al. Bremelanotide for HSDD. Innov Clin Neurosci. 2022;19(1-3):24-31
- FDA Prescribing Information - Vyleesi (bremelanotide) injection
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 4 weeks
Protect from light during storage
- •FDA-approved as Vyleesi for women
- •May cause nausea, flushing, headache
- •Can cause transient blood pressure increase
- •Limit to 8 doses per month maximum
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.