Thymosin Alpha-1 (5mg) Dosage Protocol
Thymosin Alpha-1 (Tα1) is a 28-amino acid peptide originally isolated from thymic tissue. It is approved in over 35 countries as Zadaxin for hepatitis B/C and as an immune modulator. It enhances T-cell and dendritic cell function.
Add 1.0 mL bacteriostatic water → 5 mg/mL
1.6mg twice weekly (approved dose) or up to 3.2mg/day in acute settings
At 5 mg/mL: 32 units = 1.6mg (standard dose)
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 4 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Standard (Chronic) | 1.6mg | 32 units twice weekly |
| Acute/Loading | 1.6mg every 12h | 32 units twice daily |
| Maintenance | 1.6mg 2-3x weekly | 32 units per dose |
- 1Draw 1.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
Thymosin Alpha-1 enhances T-cell maturation, increases T-helper cell function, and augments dendritic cell activity. It modulates cytokine production and has been shown to restore immune function in immunocompromised states. Clinical trials for hepatitis B showed 26-week treatment with 1.6mg twice weekly.
- Approved in 35+ countries for hepatitis B/C
- Enhances T-cell and NK cell function
- Supports immune response in immunocompromised patients
- Used as adjunct therapy in cancer treatment
- Dominari A, et al. Thymosin alpha 1: A comprehensive review. Expert Opin Biol Ther. 2020;20(12):1433-43
- Zadaxin Prescribing Information - Thymalfasin 1.6mg
- Wu J, et al. Thymosin alpha 1 for sepsis. Expert Opin Biol Ther. 2015;15(sup1):S71-S81
- ClinicalTrials.gov NCT02867267 - Thymosin alpha 1 for sepsis
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 4 weeks
Subcutaneous administration preferred
- •Approved as Zadaxin in many countries (not FDA-approved in US)
- •Well-tolerated with minimal side effects
- •May be used for 6-12 months in chronic conditions
- •Clinical trials support use in sepsis at higher doses
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.