Semaglutide (5mg) Dosage Protocol
Semaglutide is a GLP-1 receptor agonist FDA-approved for type 2 diabetes (Ozempic) and chronic weight management (Wegovy). It mimics the incretin hormone GLP-1 to regulate appetite and blood sugar.
Add 2.0 mL bacteriostatic water → 2.5 mg/mL
0.25mg-2.4mg once weekly (dose escalation required)
At 2.5 mg/mL: 10 units = 0.25mg, 40 units = 1mg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 6 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Weeks 1-4 | 0.25mg weekly | 10 units (0.1 mL) |
| Weeks 5-8 | 0.5mg weekly | 20 units (0.2 mL) |
| Weeks 9-12 | 1.0mg weekly | 40 units (0.4 mL) |
| Weeks 13-16 | 1.7mg weekly | 68 units (0.68 mL) |
| Week 17+ | 2.4mg weekly | 96 units (0.96 mL) |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
Semaglutide activates GLP-1 receptors, reducing appetite, slowing gastric emptying, and improving glycemic control. The STEP clinical trials demonstrated 2.4mg weekly plus lifestyle intervention resulted in sustained, clinically relevant weight reduction averaging 15-17% body weight loss.
- FDA-approved for weight management and type 2 diabetes
- Reduces appetite and food intake
- Improves glycemic control and HbA1c
- Once-weekly dosing for convenience
- Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002
- FDA Prescribing Information - Wegovy (semaglutide) injection
- Fornes A, et al. Once-Weekly Semaglutide for Weight Management. J Pharm Technol. 2022;38(4):172-180
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 6 weeks
Semaglutide is stable; avoid freezing after reconstitution
- •Dose escalation is critical to minimize GI side effects
- •Do not increase dose faster than every 4 weeks
- •Common side effects: nausea, vomiting, diarrhea
- •Contraindicated in personal/family history of MTC
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.