PE-22-28 (10mg) Dosage Protocol
PE-22-28 is a spadin analog peptide that acts as a TREK-1 potassium channel blocker. Research suggests it may have antidepressant-like effects through this novel mechanism of action.
Add 2.0 mL bacteriostatic water → 5 mg/mL
100-500 mcg daily for research protocols
At 5 mg/mL: 2 units = 100 mcg, 10 units = 500 mcg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 2 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Weeks 1-2 | 100-200 mcg daily | 2-4 units |
| Weeks 3-4 | 200-300 mcg daily | 4-6 units |
| Weeks 5-8 | 300-500 mcg daily | 6-10 units |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall
- 3Gently swirl until fully dissolved
- 4Label with date and concentration, refrigerate immediately
PE-22-28 blocks TREK-1 potassium channels, which are involved in neuronal excitability. This mechanism is distinct from traditional antidepressants. Research in animal models showed rapid antidepressant-like effects within days rather than weeks.
- Novel mechanism of action
- Research suggests rapid onset effects
- TREK-1 channel modulation
- Studied for mood research
- Mazella J, et al. Spadin, a sortilin-derived peptide. Cell. 2010
- Moha ou Maati H, et al. The peptidic antidepressant spadin. Br J Pharmacol. 2012
- TREK-1 channel and mood research
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 2 weeks
Novel mechanism - limited stability data
- •Research compound - not FDA approved
- •Novel mechanism with limited human data
- •Not a substitute for psychiatric medications
- •Consult healthcare provider for mood concerns
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.