NAD+ Precursor (NMN) (500mg) Dosage Protocol
Nicotinamide Mononucleotide (NMN) is a NAD+ precursor that supports cellular energy metabolism and has been studied for anti-aging effects. Injectable forms provide higher bioavailability than oral.
Add 3.0 mL bacteriostatic water → 166.7 mg/mL
50-100mg subcutaneously or 250-500mg orally
At 166.7 mg/mL: 30 units = 50mg, 60 units = 100mg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 2 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Injectable | 50-100mg | Once daily SC |
| Oral | 250-500mg | Once daily |
| Duration | Continuous | Long-term use |
- 1Draw 3.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
NMN is converted to NAD+ via the salvage pathway. NAD+ is essential for sirtuins, PARPs, and CD38 enzymes involved in DNA repair, metabolism, and aging. Human trials (250mg/day oral) showed increased NAD+ levels and improved insulin sensitivity. Injectable forms bypass first-pass metabolism.
- Increases cellular NAD+ levels
- Supports mitochondrial function
- May improve insulin sensitivity
- Research suggests anti-aging effects
- Yoshino J, et al. NMN and NAD+ metabolism. Cell Metab. 2018;27(3):513-28
- Igarashi M, et al. NMN in healthy humans. NPJ Aging. 2022;8(1):5
- Shade C. The science behind NMN. Integr Med. 2020;19(1):12-14
Lyophilized
Store at -20°C, protected from light and moisture
Reconstituted
Refrigerate at 2-8°C, use within 2 weeks
NMN is hygroscopic - protect from moisture
- •Not FDA approved as drug - sold as supplement
- •Human clinical trials ongoing
- •Injectable form has higher bioavailability
- •Long-term safety data still accumulating
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.