FOX04-DRI (10mg) Dosage Protocol
FOXO4-DRI is a cell-penetrating peptide designed to disrupt the FOXO4-p53 interaction in senescent cells. Research suggests it may selectively induce apoptosis in senescent cells (senolytic activity).
Add 2.0 mL bacteriostatic water → 5 mg/mL
5-10 mg per injection, intermittent dosing
At 5 mg/mL: 100 units = 5 mg, 200 units = 10 mg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 2 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Protocol option 1 | 5 mg every 3 days | 100 units x 3 doses |
| Protocol option 2 | 10 mg weekly | 200 units once weekly |
| Duration | 3-4 weeks | Then extended break |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall
- 3Gently swirl until fully dissolved
- 4Label with date and concentration, refrigerate immediately
FOXO4-DRI is a D-retro-inverso peptide that penetrates cells and disrupts the FOXO4-p53 interaction. In senescent cells, this interaction prevents apoptosis. By blocking it, FOXO4-DRI may selectively induce senescent cell death while sparing healthy cells.
- Selective senolytic activity
- Targets senescent cells specifically
- Research in aging and longevity
- May reduce senescent cell burden
- Baar MP, et al. Targeted apoptosis of senescent cells. Cell. 2017
- FOXO4-DRI senolytic research studies
- Senescent cell clearance and aging research
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 2 weeks
Intermittent dosing - not for daily use
- •Research compound - not FDA approved
- •Intermittent dosing protocol essential
- •Limited human safety data
- •Part of senolytic research field
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.