Dihexa (10mg) Dosage Protocol
Dihexa is a hexapeptide derived from angiotensin IV that acts as a hepatocyte growth factor (HGF) mimetic. Research indicates potent nootropic effects at very low doses, enhancing synaptic connectivity.
Add 10 mL bacteriostatic water → 1 mg/mL (1000 mcg/mL)
10-30mg sublingually or 1-5mg subcutaneously
At 1 mg/mL: 10 units = 100 mcg, 100 units = 1mg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 4 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Sublingual | 10-30mg | Once daily |
| Subcutaneous | 1-5mg | Once daily |
| Duration | 4-8 weeks | Cycle length |
- 1Draw 10 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
Dihexa is an HGF/c-Met receptor agonist that promotes synaptogenesis and dendritic spine formation. Animal studies showed cognitive enhancement at picomolar concentrations (10^7 times more potent than BDNF). It crosses the blood-brain barrier and may support neuroplasticity.
- Potent nootropic effects in animal studies
- Promotes synaptogenesis and spine density
- Crosses blood-brain barrier
- Active at very low concentrations
- Benoist CC, et al. Dihexa enhances cognition. J Pharmacol Exp Ther. 2014;349(1):69-78
- McCoy AT, et al. Angiotensin IV and cognition. Pharmacol Biochem Behav. 2013;105:51-7
- Wright JW, Harding JW. The brain angiotensin system and cognition. Exp Neurol. 2013;239:152-63
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 4 weeks
Sublingual administration may have lower bioavailability
- •Research compound - not FDA approved
- •Limited human safety data available
- •Extremely potent - careful dosing required
- •Developed at Washington State University
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.